Sentara椅子，教授

电话: 757-6837029

电子邮件: jcatrava@mokmingsky.com

地址: IRP 2, 4211 Monarch Way, Norfolk, VA, 23508

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Education

• 博士后RESEARCH员: Pulmonary Vascular Pathophysiology, Yale University, 1978-1980.
• 博士: 药理学 & Toxicology, University of Mississippi, 1978.
• M.S: 药理学 & Toxicology, University of Mississippi, 1975.
• B.S.: 化学 & 物理学，康奈尔大学，1972年

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实验室成员

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RESEARCH描述

The mission of the Laboratory of Pulmonary Endothelial & Parenchymal Pathophysiology is to perform basic and translational research and training of new investigators aimed at improving the diagnosis, 预防, and treatment of acute and chronic lung diseases.

其他e are seven active projects under investigation:

I. Endothelial barrier dysfunction, protection, and repair in ARDS. Acute respiratory distress syndrome (ARDS) is a rapidly progressive disease occurring in critically ill patients. The main complication in ARDS is that fluid leaks into the lungs making breathing difficult or impossible. Among others, it is the cause of death of COVID-19 patients.

1) Endothelial barrier dysfunction in ARDS; protection and repair by HSP90 inhibitors.

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2) Alveolo-capillary injury in ARDS; protection and repair by PTP4A3 inhibitors (with 约翰年代. Lazo, Ph值.D.KeViRx).

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3) Murine models of SARS-CoV-2 induced COVID-19; protection and repair by PTP4A3 inhibitors (with 约翰年代. Lazo, Ph值.D.KeViRx).

II. Antidotes Against Chemical-Induced Chronic Lung Injury. Pulmonary fibrosis is a lung disease that occurs when lung tissue becomes damaged and scarred. This thickened, stiff tissue makes it more difficult for lungs to work properly. As Pulmonary Fibrosis worsens, one becomes progressively short of breath.

1) Antidotes against hydrochloric acid-induced chronic lung injury and Pulmonary Fibrosis. Antidotes: HSP90 inhibitors, auy - 922, AT13387, TAS-169.

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2) Antidotes against hydrochloric acid-induced chronic lung injury and Pulmonary Fibrosis. 解药:植物雌激素，染料木素.

3) Antidotes against mustard (CEES)-induced chronic lung injury and Pulmonary Fibrosis. Antidote: PTP4A3 inhibitors (with Stephen Beebe, Ph.D. 和Brittney Ruedlinger博士.D.约翰·拉佐，博士.D.KeViRx)

3. Lung capillary recruitment and loss in patients with pulmonary hypertension. This project utilizes patients suspected of, or at risk for pulmonary hypertension to test the hypotheses that the lung accommodates blood flow differently during pulmonary hypertension due to the loss of capillaries and that the magnitude of capillary loss may determine the type of appropriate pharmacological management. David Langleben, m.s.D.麦吉尔大学. 斯蒂利亚诺斯·奥尔法诺斯，m.s.D., U. 雅典.

方法 & 技术

为了进行这些RESEARCH, multiple methodological approaches are utilized, 包括, 基因/分子(e.g., real-time PCR, immunoblotting), cellular (e.g., cell culture, immunostaining, measurements of transcellular electrical resistance), analytical (e.g.动物;动物.g., in vivo: mice, rabbits; ex-vivo: bronchoalveolar lavage, histology) and clinical.

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资金

这项工作得到了几个机构的支持, 包括 the National Institute of Environmental 健康 Sciences and the National Heart Lung and Blood Institute of the National Institutes of 健康, Sentara捐赠给P.I., 老自治领RESEARCH基金会, KeViRx and the McGill/Jewish General Hospital Division of Cardiology.

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网站登录

教授. 约翰D. 卡特拉瓦斯教授. 约翰年代. Lazo项目获得NIH SBIR资助

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最相关的出版物

1. Colunga Biancatelli RML, Solopov PA, Sharlow ER, Lazo JS, Marik PE, Catravas JD. The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells. J - Physiol是肺细胞Mol - Physiol. 321(2):L477-L484, 2021.
2. Solopov P, Biancatelli RMLC, Marinova M, Dimitropoulou C and Catravas JD. HSP90抑制剂, auy - 922, Ameliorates the Development of Nitrogen Mustard-Induced Pulmonary Fibrosis and Lung Dysfunction in Mice. 生物医学杂志. 3: 21(13):4740, 2020.
3. Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J. 氢化可的松, 维生素C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. 胸部. 2017年6月,151 (6):1229 - 1238. PMID: 27940189.
4. Langleben D, Orfanos SE, Giovinazzo米, 施莱辛格路, 赫希是, Blenkhorn F, Lesenko L, Armaganidis一, Catravas JD. Acute vasodilator responsiveness and microvascular recruitment in idiopathic pulmonary arterial hypertension. Ann实习医生. 162:154-6, 2015. PubMed PMID: 25599356.
5. Catravas J.D. 沃特斯，我.W. Acute cocaine intoxication in the con­scious dog: Studies on the mechanism of lethality. J. Phar-macol. 经验值. 其他. 217: 350-356, 1981.

奖项及荣誉

• Established Investigator of the American Heart Association, 1985‑1990;
• Outstanding RESEARCH Award, American Lung Association, Georgia Affiliate, 1991;
• 福格蒂高级国际RESEARCH员，1993年;
• 1993年Burroughs - Wellcome旅游奖;
• 董事教授，1995-2013;
• NIH Toxicology 2 Study Section: 1990-1994;
• SE AHA Committee 1A Study Section: 2005-2008 (Chair: 2006-08);
• Fellow, Council of Basic Cardiovascular Sciences, American Heart Association;
• 美国生理学会会员;
• Fellow, American College of 胸部 Physicians;
• 主编, 血管药理学(1999-2011);
• 现任编辑委员会: American Journal of Physiology: Lung Cell and Molecular Physiology, Pneumon, 开放一氧化氮杂志, 实验药理学杂志, 血管放射学杂志;
• Current member to the NHLBI K08 review Study Section, Diversity K01 Study Section and the CounterACT Study Section.